A study published in June 2021 by Arthritis Care & Research focused on understanding whether vitamin D supplementation or maintaining sufficient vitamin D concentrations can reduce foot pain caused by knee osteoarthritis.
This is an important topic because degenerative joints are a chronic, global disease characterized by pain and deformation of the joints. The global prevalence of osteoarthritis in people over 60 is about 10% in men and 20% in women. The financial burden on the overall economy of Western countries is estimated to be about 1.0-2.5%, and the impact is indeed not low.
Foot pain is a very common musculoskeletal pain, often defined as pain that occurs in the foot and/or ankle. It affects about 1/5 of elderly patients in the community and seriously affects the quality of life.
Foot pain often accompanies knee pain, and foot pain can impair physical activity, reduce quality of life, and depress the patient's mood.
In an article published in Arthritis Rheum in 2005, a study of 8990 elderly people showed that knee pain often causes joint pain all over the body, especially foot pain, so it should not be taken lightly. Therefore, the treatment of foot pain is of great significance to the degenerative joint of the knee.
The so-called vitamin D deficiency is usually defined as the concentration of 25-hydroxyvitamin D in serum <50 nmoles/liter; while vitamin D deficiency is defined as the concentration between 50-75. Past research has linked vitamin D deficiency with chronic musculoskeletal pain and depressed mood.
This study used a randomized, double-blind, controlled clinical trial. Subjects were symptomatic knee osteoarthritis patients with serum vitamin D concentrations ranging from 12.5 to 60, and then took vitamin D3 or placebo for 2 years. The Manchester foot pain and disability index (MFPDI) was used to track and analyze foot pain and disability.
The results showed that among the 413 patients enrolled in the study, the mean age was 63.2 years, 19.7% were male, of which 340 patients completed the study, and their mean MFPDI was 22.8 ± 7.3, of which 23.7% were disabled before treatment. Two years later, there was a significant difference between the two groups, with the vitamin D group being significantly better than the placebo group.
The conclusion is that vitamin D supplementation and maintaining sufficient vitamin D concentration can indeed improve the foot pain of knee osteoarthritis.
Reposted to: Zhang Deming Rheumatology Library